SHUTTERSTOCKMigraines can result from certain genes, a stressful life, environmental conditions or some changes in your diet. They often develop in your 20s to 40s.Various medications and therapies can provide relief, but the FDA has approved the first in a new class of drug aimed at heading off migraine headaches before they start. There are headaches, and then there are migraines.“Oh, my god. I can’t tell you how disabling migraines can be,” said Dr. Priyanka Chaudhry, a neurologist at Baylor University Medical Center specializing in headaches.“When patients come to me, they often say, ‘When I have a bad headache, I’m missing a social event. I’m missing time with my family. I can’t go out or do work.’ So, it’s that disabling.”The new drug is a CGRP monoclonal antibody developed to prevent headaches.“It’s a once-a-month injection used to decrease the number of headache days that they have in a month,” Choudhry said. “In some cases, it will also make sure that you have less intense headache or the duration of the headache actually goes down.”Interview HighlightsOn the importance of the new drug: This is the most exciting phase in the headache world because in the last several years, we have not had a new drug which has been developed specifically for migraine. This drug is a CGRP monoclonal antibody. The fancy name is “calcitonin gene-related peptide,” which basically was developed to prevent headaches or to use it as a rescue. It’s one-of-a kind because CGRP is released when someone has a migraine or a head attack and [the drug] actually helps to inhibit or to antagonize the effects of CGRP.How the new drug works: It’s a once-a-month injection used to decrease the number of headache days that they have in a month. In some cases, it will also make sure that you have a less intense headache or the duration of the headache actually goes down.How the new drug differs from current medication: We use two kind of medications now: One is rescue, usually use triptans or over-the-counter inserts, and then, preventives like antidepressants, anti-nausea medication, antihypertensive — something you use once a day. The problem with preventives is the high side effects and it takes a long time for them to work.What we’re noticing with this new drug is that patients don’t really get much side effects. Also, it works a lot faster. It works within a month where as some of the other drugs can take eight to 10 weeks to show an efficacy.The drug’s cost ($6,900 per year, depending on insurance): The company is providing at least two doses free, which means you get to experience the drug and see if it’s even worthwhile. And then the company will work with your insurance and try writing preauthorization letters and letters of appeal to see if we can get you on the drug.Hopefully, I’m assuming, when insurance companies start seeing how much it prevents patients from going to the ER, how much it prevents patients coming to doctors again and again for headaches and it helps with their migraine, this will soon be on most commercial plans. Other similar medications to come: There are three more in the pipeline and hopefully we’ll have some of those by the end of the year. There is one more that is presumed to come next year, hopefully.Are we close to a cure for migraine: No. We can improve the quality of life with these medications to the point where patients either don’t have that many headaches or when they have a headache, they’re able to break it pretty quickly so they can go back to what they were doing. The problem is that there is no real path of physiology of migraine.Migraine can happen due to various reasons. There are several theories that we know, but there’s just one pathway that we know. However, with this new drug, we are a lot closer than we were a couple of years ago to finding a good, happy balance to someone having a migraine but still having a great quality of life. Share
One year ago, the Brightwood Park neighborhood, a predominantly residential area in northwest Washington, D.C. just north of Howard University, welcomed a not-so-ordinary coffee shop called Culture Coffee.It’s a place where local vendors serve up much of the daily menu, such as Quentina Hampton’s breakfast quiches and 81-year-old Christien Thomas’s lemon pound cake.Step into Culture Coffee and, depending on the day or time, you may find yourself in the midst of an open-mic poetry reading, a neighborhood book club meeting, a birthday party or just a local community gathering. Lining the walls are the works of local artists for sale that you won’t find at Starbucks or Dunkin’ Donuts.“We have a space for pretty much anything you like,” said Saundrell Stevens, one of the café’s co-owners. “It’s not your typical coffee house.”Veronica Cooper, the other owner, agreed.“We are named Culture Coffee because we cater to different age, education and ethnic groups,” Cooper said. “It is really a big melting pot.”That is exactly what Cooper and Stevens had in mind for their coffee shop when they came up with the idea three and a half years ago.Stevens was frustrated about the lack of coffee shops in the neighborhood. She wanted to be able to enjoy a cup of coffee without driving miles away from home to get it. Cooper felt like coffee was speaking to her.“That Sunday of President Obama’s first inauguration, my girlfriend headed that ball,” Cooper said. “She asked me to help her put 1,000 bags of coffee in the gift bags. Every day, a coffee situation was coming up just like that.”Stevens said they both wanted something a little different from the typical coffee bar.“I wanted a nice coffee bar to go to that wasn’t so traditional,” she said. “I wanted something where people could go and sit down and get comfortable.”So far, the community has responded well.“[Culture Coffee] is far superior to Starbucks,” said Lisa Tucker, a real estate agent and frequent customer. “The local aspect and the coffee are better.”Danielle Parsons, a public health specialist, is also a fan.“Going to Culture Coffee is less about what I’m getting to drink and more about the environment, and who I might see there and who I might chat with,” said Parsons, 31.Cooper, a seamstress, and Stevens, a full-time government employee, took three and a half years to properly prepare for launching Culture Coffee. First, they saved money from their income. Next, they took out a Small Business Association loan worth $100,000. They put together a business plan and submitted it to a bank for approval.“After that, you find a location,” Stevens said. “We had the location maybe six months before we actually got approved for the loan. We just knew it was going to happen. You have to believe.”Culture Coffee opened for business on Nov. 2, 2013.“I was very nervous,” Stevens said. “I did not sleep at all, but I was very excited.”They sell coffee, tea, smoothies, milkshakes and wine, and sandwiches, pastries, salads, snacks and breakfast food are also on the menu. Not only do they boast an extensive menu, but all items are affordable.“Certain things are cheaper than at Starbucks, and they taste better,” customer Nishon Brown said.With their extensive and inexpensive menu and openness to the community, Culture Coffee is exactly what Cooper and Stevens envisioned. However, Cooper and Stevens said the business has not been profitable yet.“Business is steadily growing, a nice, even, slow pace, nothing fast,” Cooper aid. “It is a slow, steady climb.”Culture Coffee is open Monday through Friday from 7 a.m. to 4 p.m., Saturday from 8 a.m. to 6 p.m. and Sunday from 10 a.m. to 5 p.m.
Kolkata: The state Urban and Municipal Affairs minister Firhad Hakim visited Dakshineswar Skywalk on Tuesday.The Skywalk will be inaugurated by Chief Minister Mamata Banerjee on November 5. On his visit to the skywalk on Monday, Hakim said: “The wait is going to end and the hope of many is going to get real. The Skywalk will be of great help to people and also clear crowds fast,” Hakim said adding that people no more have to walk on the road to reach the temple. Instead, they can safely take the Skywalk and reach the temple. Also Read – Rain batters Kolkata, cripples normal lifeHakim inspected the Skywalk before it gets inaugurated and also spoke to the locals about it. He further said: “Feasibility to construct a Skywalk at Kalighat is being checked upon. The project will be taken up if it is found feasible.” The residents of the locality have congratulated the state government for constructing the Skywalk and its decision to inaugurate it ahead of Kali Puja. During Kali Puja, thousands of devotees visit Dakshineswar and approximately 1.3 crore devotees turn up at the temple in a year. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedIt has come up at a cost of Rs 65 crore and the 340 m long Skywalk that is fitted with four elevators and 12 escalators ensures an easy connectivity to and from the temple. It will help in reducing traffic congestion in the area and pedestrians will no more have to worry about getting stuck due to vehicular movement when they are headed towards the temple or return from the same. There are also staircases that can one avail while using the Skywalk. Interestingly, one can also buy various stuff while on the Skywalk as there are spaces for around 200 shops there. According to the locals, the Skywalk is a landmark architecture and has given a complete new look to the area. People from various countries visit Dakshineswar every year. The Skywalk at Dakshineswar is a gift from the state government to its people ahead of Kali Puja. It is expected that with the construction people no more have to face rush while entering the temple premises on the days of Kali Puja and Diwali.
2 min read Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Growing a business sometimes requires thinking outside the box. February 7, 2014 Amazon wants a House of Cards of its own.The digital retailer and streamer of programming through its Prime Instant Video service is hoping to seduce binge watchers by creating original content, treading a similar path forged by Netflix to swelling viewership and artistic acclaim.But Amazon will not rely on network executives to program its airwaves, because viewers themselves have been tasked to decide which series will get the green light.For the second year in a row, the company’s production arm, Amazon Studios, has released 10 pilots for free online streaming, sponsored by Geico. Viewers will have approximately two months to rate, criticize and opine, upon which Amazon will proceed with production based on crowdsourced feedback.Related: Amazon Just Bought a Video-Game CompanyWhile last April’s initial run featured eight comedies and six children’s shows, this is the first time that the company is tossing hour-long dramas into the mix in hopes of conceiving a flagship series of its own. These include cop drama Bosch and post-apocalyptic The After, from the creator of The X-Files.Budgets and production value are on par with that of network competitors, Ron Price, director of Amazon Studios, told The Verge.This year’s batch of shows also includes three more comedies and five additional kids’ series. Last year’s running yielded Alpha House and Betas, about dating app developers in California seeking an investor, though neither resonated to the extent of Netflix’s award-winning hits like Cards and Orange Is the New Black.Related: Your Amazon Prime Subscription May Get More Expensive Register Now »
S.E.E.-ing is believing with brand new lineup of Sandals, Beaches fams << Previous PostNext Post >> Tags: Sandals Share Travelweek Group TORONTO — Sandals Resorts has launched a new series of 17 Sandals Educational Experience (S.E.E.) travel agent fam trips from July through October 2018, all with no land cost.The company says its new series of S.E.E. fam trips invites agents to not only learn through interactive resort updates and presentations but also “to personally experience everything that Sandals & Beaches has to offer their clients”.A total of 17 S.E.E. fam trips are available this summer and fall, with three to four nights at various properties including Sandals Grande Antigua, Sandals Grenada, Sandals Barbados, Sandals Montego Bay and Beaches Turks & Caicos.Each itinerary includes a mix of scheduled activities and free time for agents to enjoy the resorts.Space is limited and agents are encouraged to register early to avoid disappointment. Registration takes place exclusively on Sandals’ travel agent portal taportal.sandals.com under the ‘Events’ section.Air is not included and Sandals says agents should wait to receive confirmation before securing their flights.More news: Consolidation in the cruise industry as PONANT set to acquire Paul Gauguin CruisesTo take part in a fam agents are required to complete a Certified Sandals Specialist (CSS) workshop and book and register at least one booking on the travel agent portal.Here’s the schedule:JULYJuly 7 – 10: Sandals Grande AntiguaJuly 22 – 25: Sandals GrenadaJuly 29 – Aug. 1: Sandals GrenadaAUGUSTAug. 11 – 14: Sandals Grande AntiguaAug. 27 – 30: Sandals Grande St. LucianAug. 28 – Sept. 1: Sandals South Coast and Sandals Montego BayAug. 29 – Sept. 1: Sandals Grande AntiguaSEPTEMBERSept. 8 – 12: Beaches Ocho Rios and Sandals Montego BaySept. 10 – 13: Beaches Turks & CaicosSept. 15 – 19: Sandals South Coast and Sandals NegrilSept. 17 – 20: Sandals Regency La TocSept. 27 – 30: Sandals BarbadosSept. 30 – Oct. 4: Sandals Montego Bay and Sandals South CoastOCTOBEROct. 1 – 4: Beaches Turks & CaicosOct. 5 – 8: Sandals BarbadosOct. 27 – 3: Sandals Regency La TocOct. 29 – Nov. 1: Beaches Turks & CaicosMore news: Onex paying big to get WestJet and that will send airfares soaring, says CWTFor more information, agents can contact their local Business Development Manager or call Inside Sales at 1-800-545-8283.* This article was updated at 4 p.m. on May 1 to reflect revised information from Sandals Resorts. Tuesday, May 1, 2018 Posted by